Cas-CLOVER, developed by Hera BioLabs, is functionally similar to CRISPR-Cas9 but uses a different nuclease protein called Clo51. Thus, Cas-CLOVER is a fusion protein that comprises a nuclease-inactivated Cas9 protein fused to the Clo51 endonuclease. Compared to CRISPR-Cas9, it demonstrates higher fidelity with no detectable off-targets while maintaining robust editing efficiency.
[www.herabiolabs.com]