www.czu.cz ; www.usab-tm.ro ; www.raupp.info

There is current debate whether genetically modified (GM) plants might
contain unexpected, potentially undesirable changes in overall metabolite
composition, September 2005 by John Draper et al. .

However, appropriate analytical technology and acceptable metrics of
compositional similarity require development. We describe a comprehensive
comparison of total metabolites in field-grown GM and conventional potato
tubers using a hierarchical approach initiating with rapid metabolome
"fingerprinting" to guide more detailed profiling of metabolites where
significant differences are suspected.

Central to this strategy are data analysis procedures able to generate
validated, reproducible metrics of comparison from complex metabolome data.
We show that, apart from targeted changes, these GM potatoes in this study
appear substantially equivalent to traditional cultivars.

Gareth S. Catchpole, Manfred Beckmann, David P. Enot, Madhav Mondhe, Britta
Zywicki, Janet Taylor, Nigel Hardy, Aileen Smith, Ross D. King, Douglas B.
Kell, Oliver Fiehn, and John Draper

Link to the full article:
[www.pnas.org]

[www.pnas.org]

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