www.checkbiotech.org ; www.raupp.info ; www.czu.cz

Plants and agriculture have played an important role in the development and
advancement of civilization, and with genetic engineering, their role stand
to become even more important, October 2005 by Richard Hamilton,Chief
Executive Officer, Ceres, Inc., a privately held biotechnology company;
Richard B. Flavell, Chief Science Officer, Ceres, Inc.; Robert B. Goldberg,
Professor of Molecular, Cell, and Developmental Biology, University of
California, Los Angeles.

Plants provide sustainable supplies of food for humans, feed for animals,
fiber for construction and clothing, medicines and drugs, perfumes,
chemicals for industrial processes, energy for cooking and heating, and,
most recently, biomass to meet the increasing demand for transportation
fuels.

Plants also play a major environmental role by preventing soil erosion,
boosting levels of oxygen in the atmosphere, reducing carbon dioxide
emissions from burning fossil fuels, and enriching soils with nitrogen,
which they cycle between soil and the atmosphere.

Agriculture In The 21st Century

If population growth continues as predicted, we will need to produce more
food, feed, and fiber during the next 50 years than in the entire history of
humankind. And we will need to do this on a decreasing amount of land that
is suitable for agriculture and crop production.

This presents several major challenges for 21st-century agriculture:

Crop yields need to be increased beyond the spectacular gains of the 20th
century in order to meet increasing demand and save open space.


Inputs required for intensive agriculture, such as water and fertilizers,
need to be reduced.


Crops need to be developed that can flourish in harsh conditions so that
substandard land can be used to grow important crops, growing seasons can be
extended, and yields are not decreased by drought, heat, cold, and other
stresses.


The environmental impacts of agriculture resulting from the use of
pesticides, herbicides, and fertilizers need to be reduced. For example,
crops need to be engineered that are resistant to pests, that take up
nutrients more effectively from the soil, and that can out-compete weeds for
water and sunlight.


Food crops need to be optimized for human health and nutrition, providing
essential vitamins, amino acids, and proteins to help eliminate malnutrition
and disease.


Novel energy crops need to be developed that are high yielding and that can
be used as a renewable source of biomass for fuels to limit our dependence
on a petroleum-based energy system.


We need to go ?back to the future? and engineer specialty crops that can be
used as factories to produce chemicals and proteins for industrial and
medical applications -- for example, plastic precursors and vaccines to
combat human and animal pathogens.

These challenges will require application of the most sophisticated breeding
and molecular techniques available today, as well as the development of new
ones. Nevertheless, there has never been a more exciting time for plant
biology and agriculture, and the technological revolution created by the
genomics era provides a unique opportunity to achieve these goals over the
next two decades or sooner.

Using Biotechnology To Develop New Crops

Most of the crops that we grow today did not spring forth from a mythical
Garden of Eden and do not grow ?naturally.? To the contrary, most major
crops were engineered by our ancestors thousands of years ago from wild
relatives by selecting and breeding for traits that optimized crops for
human use.

These early genetic engineers learned how to recognize random mutations that
appeared in wild plant populations and to use this genetic variability to
create the food crops that we use today. For example, maize was bred from
teosinte grass 10,000 years ago by selecting for a few genes that control
cob size, seed structure and number, and plant architecture.

Almost all of the crops that we use today, such as wheat, soybean, rice,
potato, cabbage, broccoli, and tomato, were engineered in an analogous
manner; that is by use of breeding technologies to create new gene
combinations within a crop species and then selecting for better traits in
the progeny.

The most significant innovations that are transforming agriculture are
genetic engineering technologies that allow novel genes to be isolated,
manipulated, and re-inserted into crop plants; the ability to regenerate
almost any plant species from tissue culture into a fertile plant; and the
development of high-throughput genomic technologies. The latter permits the
mapping and sequencing of entire plant genomes and the identification of
genes that control all plant processes, including those that can contribute
to meeting the challenges of agriculture in the future, such as genes for
disease resistance, drought resistance, seed size, and number.

At the genetic level, crop breeding depends on randomly introducing
mutations, or genetic variability, into a plant?s genome and then selecting
from a large population the small subset of changes that result in a
positive change. In the vast majority of cases, the genetic changes that are
made are unknown.

By contrast, genetic engineering affords a more precise alternative to
breeding, and, because of its precision, it can be used to develop new,
valuable traits in a small fraction of the time required to pursue the
relatively imprecise techniques of breeding.

Genes that have been characterized extensively can be introduced into crop
plants in a precise and directed way in order to generate novel, genetically
enhanced crops with traits that would not be possible to achieve using
classical breeding procedures.

The Growth And Benefits Of Biotech Crops

The first genetically engineered crops developed in the early 1980s were
resistant to herbicides and insects. Today, these two traits ? herbicide and
insect resistance ? account for the majority of biotech crops. Over the past
20 years, there has been a worldwide effort to isolate genes that will
provide a long list of traits that breeders, farmers, consumers, and
industrialists have nominated for improvement in a variety of crops.

Plant biotechnology and genetic engineering is now a major activity in the
public and private sectors and is becoming a significant part of plant
breeding on all continents. In fact, there has never been a more exciting
time for agriculture because powerful genomic technologies make it possible
to identify genes that have the potential for revolutionizing crop
production over the next 50 years.

In 2005, we celebrate 10 years of biotech crop cultivation. During that
period, 400 million hectares of genetically enhanced biotech crops have been
grown. Biotech crops have been adopted by farmers all over the globe at a
rate faster than any crop varieties in the history of agriculture -- even
faster than high-yielding hybrid maize during the last century.

Since their introduction in 1996, the use of genetically enhanced biotech
crops has grown at a rate of more than 10 percent per year, and in 2004,
according to a report of the International Service for the Acquisition of
Agri-biotech Applications, their adoption increased 20 percent.

The main crops carrying new biotech genes are soybean, maize, cotton, and
canola, accounting, respectively, for 56 percent, 14 percent, 28 percent,
and 19 percent of the worldwide acreage for these crops. Together, they
occupy nearly 30 percent of the global area devoted to these crops.

In the United States, biotech soybean (herbicide resistant), maize
(herbicide and insect resistant), and cotton (herbicide and insect
resistant) account for approximately 85 percent, 75 percent, and 45 percent
of the total acreage for these crops.

The United States is the leading grower of biotech crops, with more than 48
million hectares, followed by Argentina (16 million hectares), Canada (6
million hectares), Brazil (4.8 million hectares), and China (4 million
hectares). The value of biotech crops is nearly $5 billion, representing 15
percent and 16 percent of the global crop production and seed markets,
respectively.

Biotech crops are delivering benefits through more affordable food, feed,
and fiber that require fewer pesticides, conserve more soil, and provide for
a more sustainable environment. In addition, the annual income of poor
farmers in the developing world has increased significantly from the use of
biotech crops, according to recent data from the United Nations Food and
Agriculture Organization. Most of the value added has gone to those farmers
rather than to the technology providers.

Concerns Limiting The Growth Of Biotech Crops

Although crops produced by using biotechnology and genetic engineering have
been adopted at warp speed and are the most tested and studied crops in
human history, agricultural biotechnology is not without controversy.
Opposition to the use of biotechnology and genetically engineered organisms
derived from it is largely confined to Europe, where a small but vocal group
of activists have fomented public opinion against the technology.

In an environment where non-biotechnology-related food scares over mad cow
disease and dioxin have eroded the European public?s confidence in the
regulatory oversight of their food supply, activist groups have been able to
generate substantial distrust of agricultural biotechnology.

This distrust is misplaced: The hypothetical fears have failed to
materialize after more than 10 years of safe use and more than 400 million
hectares of cropland planted with genetically enhanced varieties. There are
no known examples of ill effects of these crops in humans, and there are
demonstrable environmental benefits. [usinfo.state.gov] In fact, major
studies, which have been published in peer-reviewed journals over the past
five years, indicate that biotech crops are substantially equivalent to
their non-biotech counterparts, that yields have been increased, that
pesticide applications have been reduced, that large amounts of soil have
been conserved, and that management practices have been successful in
preventing or minimizing the resistance to insect-resistant crops. Although
no technology is without zero risk, biotech crops have proven to be as safe
as, or safer than, those produced by conventional methods.

What About The Future?

In the next decade, further advances in agricultural biotechnology will
result in crops that have improved tolerance to drought, heat, and cold;
require fewer fertilizer and pesticide applications; produce vaccines to
prevent major communicable diseases; have increases in seed size, number,
and nutritional content; and are able to regenerate in the absence of
fertilization -- fixing hybrid vigor.

Crops will also be generated that are enhanced nutritionally to help
alleviate malnutrition in the developing world. Currently, ?golden rice 2?
cultivars undergoing field testing are capable of delivering as much as 30
micrograms of beta-carotene, a precursor to vitamin A, according to a recent
article by Jacqueline Paine and others. The authors estimate that this
amount of beta-carotene should provide at least 50 percent of the
recommended daily allowance for vitamin A in a typical child?s portion of 60
grams of rice.

Beyond applications to increase production of food, feed, and fiber,
biotechnology is making a substantial contribution to the energy area.
Advances in biotechnology have enabled the production of large amounts of
inexpensive cellulases that can be used to convert cellulose to simple
sugars that can, in turn, be fermented into fuels such as ethanol.

Recent estimates from the U.S. Department of Energy indicate that the United
States could obtain 30 percent or more of its transportation fuels from
biomass sources by 2020. Agricultural biotechnology has the potential to
increase this number even further by enhancing biomass yield density,
improving the processing characteristics of the biomass feedstock, and
decreasing the need for agronomic inputs such as water, fertilizer, and
pesticides.

Several key countries, notably the United States and China, are pushing
ahead in agricultural biotechnology, making the necessary investments in
research and development and providing a viable regulatory system for the
introduction and commercialization of new bio-enhanced crops.

If we are going to create a new kind of agriculture in the 21st century that
is both sustainable and productive with respect to food security and energy
self-sufficiency, we will need to use all of the scientific tools and
discoveries at our disposal, including biotechnology and genetic
engineering, and to follow the continuous path of agricultural breakthroughs
that have advanced human progress for thousands of years.

Distributed by the Bureau of International Information Programs, U.S.
Department of State. Web site: [usinfo.state.gov]

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