Recently, the Calcineurin B-like (cbl) gene was inserted in tobacco
(Nicotiana tabbacum) to render it salt tolerant. A team led by Premendra
Dwivedi of CSIR-Indian Institute of Toxicology Research assessed the
allergenic potential of the cbl gene product and compared its effects to
wild-types (WT).

Analysis revealed no significant similarities between the CBL protein and
known allergens. Moreover, there was no difference found between the
proteins of the GM and WT tobacco. Rapid digestion of the CBL protein also
indicated reduced chances of the protein to induce allergenicity. In
addition, mice injected with WT and GM tobacco proteins showed comparable
levels of clinical score and histamine levels. These findings suggest that
the cbl gene inserted in tobacco will not cause any allergic risk to
consumers.

[link.springer.com]
[link.springer.com]