Producing aflatoxin-detoxifizyme (ADTZ) in pigs is a new approach to help
control the aflatoxin (AFT) contamination of pig feed. Researchers from
Linyi University and Yanbian University in China successfully developed
transgenic pigs expressing ADTZ gene in their parotid glands.
The team found significant ADTZ activity in the saliva of 6 transgenic pigs.
Feeding trial with AFT results showed that there were significant
differences between AFT residues in the liver of transgenic pigs producing
ADTZ and the control pigs.
To investigate the inheritance of the transgene, 11 G1 transgenic pigs were
successfully obtained. The ADTZ activity in saliva of 11 G1 transgenic pigs
was found to be significant. Feeding trials with AFT results also showed
significant differences in the liver of G1 pigs and the control.
These results demonstrate that ADTZ produced in transgenic pigs could
improve the effect of the AFT contamination of feed on pigs.