By Aaron Rowe

Genetically engineered peanuts may help fight the most common cause of fatal
allergic reactions to food in the United States. While the research is
unlikely to result in the creation of completely allergen-free peanuts, it
could result in fewer outbreaks and even fewer deaths.

For years now, government scientists have been testing ordinary peanuts in
the hope of finding one that cannot cause the deadly allergic reactions
which kill more than 50 Americans every year. But nature may not be able to
provide an answer.

Horticulture expert Peggy Ozias-Akins at the University of Georgia in Tifton
is taking a different tack by using genetic engineering to grow
hypoallergenic peanuts.

Most allergic reactions to peanuts are triggered by the same eleven
molecules. In theory, peanuts without the genes responsible for those
molecules would be far less likely to trigger allergic reactions.

"Some proteins cause more severe allergic reactions than others," said
Ozias-Akins.
Tackling the worst offenders first, her team has made and tested peanuts
that do not produce two proteins that are among the most intense allergens.
The research appears in The Journal of Agricultural and Food Chemistry.

The biologists shot a customized DNA sequence into the plants with a gene
gun, causing the legumes to produce hairpin-shaped RNA molecules, which halt
the production of the two proteins.

Messing with the genetic code of a plant could potentially cause the seeds
to develop improperly, change the taste of the crop, or render it more
susceptible to fungal infections. But Ozias-Akins' team found that they grow
normally and can resist a common mold without any problems.

Still, getting rid of every allergy-causing substance in peanuts would not
be easy, Ozias-Akins said. "Given the number of allergenic proteins in
peanuts, I doubt that developing an allergen-free peanut is realistic."
Although it may be impossible to make a perfectly safe peanut, clipping the
right genes out could make food accidents far less common.
www.checkbiotech.org