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Proving that a genome-edited organism is not GMO
Posted by: Prof. Dr. M. Raupp (IP Logged)
Date: February 02, 2022 09:54AM

A genome-edited agricultural product that is proven to contain no
exogenous DNA is not subject to genetically modified organism (GMO)
regulations in some countries.

However, whether such proof is definitive is often disputed.

Depending on the technique used to edit the genome, an organism may have
foreign DNA or none at all. In the proposed framework, if there is no
foreign DNA involved, the resulting product can be considered as
non-GMO. In cases wherein the reagents or culture medium may have
foreign DNA, then the resulting product must be tested for the presence
of foreign DNA. Locations in the genome where the foreign DNA is likely
to be integrated will be identified then these areas will be analyzed
through several assays including target DNA sequencing, whole genome
sequencing, and genomic Southern blots. If the presence of foreign DNA
is confirmed, then the product will be considered aGMO.

According to the authors, having a clear framework will enhance the
reliability of the relevant regulations, especially in countries with
existing biosafety protocols.

Proving that a genome-edited organism is not GMO: Trends in
Biotechnology (

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