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CRISPR-targeted mutagenesis of mitogen-activated protein kinase phosphatase 1 improves both immunity and yield in wheat
Posted by: Prof. Dr. M. Raupp (IP Logged)
Date: February 23, 2024 05:12AM

Researchers used CRISPR-Cas9 in wheat, which improved its resistance to rust
and increased its yield. Their findings offer germplasm resources that can
be used for the breeding of high-resistance and high-yield plants.

The immune system of plants is regulated positively and negatively by
different factors. An example of a negative regulator of plant immunity is
MAP kinase phosphatase1 (MKP1). However, the molecular mechanisms involving
MKP1's regulation of wheat (Triticum aestivum) are currently unclear.

Scientists from different institutions studied MKP1's role in wheat defense
against two fungal pathogens. The team used CRISPR-Cas9 to knock down MKP1,
which boosted the wheat's resistance to rust brought by Puccinia striiformis
f. sp. tritici (Pst) and powdery mildew brought by Blumeria graminis f. sp.
tritici (Bgt). When compared with wild-type control plants, the mutated
plants also had higher yields.


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